General Information

  • ID:  hor005616
  • Uniprot ID:  P09929
  • Protein name:  Pigment-dispersing hormone
  • Gene name:  NA
  • Organism:  Romalea microptera (Eastern lubber grasshopper) (Romalea guttata)
  • Family:  Arthropod PDH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Romalea (genus), Romaleinae (subfamily), Romaleidae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0009416 response to light stimulus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NSEIINSLLGLPKLLNDA
  • Length:  18(69-86)
  • Propeptide:  MTAMAVSGKLLTALVLSTYILGLALTIQATQYEEDKYQENEVKYGRELASWLAQLAHKNEPAICAHKRNSEIINSLLGLPKLLNDAGRK
  • Signal peptide:  MTAMAVSGKLLTALVLSTYILG
  • Modification:  T18 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Capable of inducing pigment dispersion in the chromatophores of the fiddler crab Uca pugilator.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q7Q7R8-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005616_AF2.pdbhor005616_ESM.pdb

Physical Information

Mass: 222765 Formula: C85H146N22O28
Absent amino acids: CFHMQRTVWY Common amino acids: L
pI: 4.18 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 8
Hydrophobicity: 26.67 Boman Index: -1061
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 157.22
Instability Index: 3582.78 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3818616
  • Title:  Primary structure of an analog of crustacean pigment-dispersing hormone from the lubber grasshopper Romalea microptera.